Clinical References for 03Balance Supplements

1. Kidd PM.
   Attention deficit/hyperactivity disorder (ADHD) in children: Rational for its integrative management.
   Alternative Medicine Reviews 2000; 5: 402-428.
2. Kimberly R Tyeryar, Habiba OU Vongtau and Ashiwel S Undieh.
   Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain.
   BMC Neuroscience 2008, 9:12 doi:10.1186/1471-2202-9-12Accepted: 24 January 2008.
3. L. Svennerholm, K. Boström, B. Jungbjer, and L. Olsson.
   Membrane Lipids of Adult Human Brain: Lipid Composition of Frontal and Temporal Lobe in Subjects of Age 20 to 100 Years
   Journal of Neurochemistry 1994: 63, Pages 1802 – 1811.
4. E Carlini, L Corazzi, O Camici, G Arienti.
   The fate of phosphatidylethanolamine formed by decarboxylation in rat brain mitochondria.
   Biochem Mol Biol Int 1993 29: 821-9.
5. Sakamoto T, Cansev M, Wurtman RJ.
   Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus.
   Brain Res. 2007; 1182:50-9.
6. Cansev M, Wurtman RJ, Sakamoto T, Ulus IH.
   Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses.
   Alzheimer’s Dement. 2008;4:S153-68.
7. Wurtman RJ.
   Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents.
   Metabolism. 2008;57 2:S6-10.
8. Holguin S, Huang Y, Liu J, Wurtman R.
   Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats.
   Behav Brain Res. 2008 ;191:11-6.
9. Schaefer EJ, Bongard V, Beiser AS, et al.
   Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study.
   Arch Neurol. 2006;63:1545-50.
10. Bourre JM.
    Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing.
    J Nutr Health Aging. 2004;8:163-74.
11. Bourre JM.
    Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain.
    Part 2 : macronutrients.
    J Nutr Health Aging. 2006 ;10:386-99.
12. Harun K. M. Yusuf, John W. T. Dickerson, and John C. Waterlow.
    Changes in content and composition of brain phospholipids in malnourished children.
    Am. J. Clin. Nutr. 32: 2227-2232, 1979.
13. Mohammed Akbar, Frances Calderon, Zhiming Wen, and Hee-Yong Kim.
    Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival.
    Proceeding of the National Academy of Sciences. 2005; 102: 10858-10863.
14. Spencer JP.
    Flavonoids: modulators of brain function?
    Br J Nutr. 2008;99 E Suppl 1:ES60-77.
15. Spencer JP.
    Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance.
    Proc Nutr Soc. 2008;67:238-52.
16. Schroeter H, Spencer JP, Rice-Evans C, Williams RJ.
    Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.
    Biochem J. 2001;358(Pt 3):547-57.
17. Nakamura M, Omura S.
    Quercetin regulates the inhibitory effect of monoclonal non-specific suppressor factor beta on tumor necrosis factor-alpha production in LPS-stimulated macrophages.
    Biosci Biotechnol Biochem. 2008;72:1915-20.
18. Mukherjee PK, Chawla A, Loayza MS, Bazan NG.
    Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease.
    Prostaglandins Leukot Essent Fatty Acids. 2007;77(5-6):233-8.
19. Frank Thies, Gerhard Nebe-von-Caron, Jonathan R Powell et al.
    Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y1–3
    Am J Clin Nutr2001;73:539–48.
20. Elizabeth J Johnson and Ernst J Schaefer
    Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration.
    Am J Clin Nutr 2006;83(suppl):1494S– 8S.
21. Parris M. Kidd
    Omega-3 DHA and EPA for Cognition, Behavior, and Mood: Clinical Findings and Structural- Functional Synergies with Cell Membrane Phospholipids.
    Alternative Medicine Review Volume 12, Number 3 2007.
22. U. Ingrid Richardson and Richard J. Wurtman
    Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells.
    Biochim Biophys Acta. 2007; 1771: 558–563.
23. Nicolas G. Bazan
    Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations and Alzheimer’s disease. nbazan@lsuhsc.edu.
24. Jim W. Burgess, Tracey A-M. Neville, et al.
    Phosphatidylinositol increases HDL-C levels in humans.
    J. Lipid Res. 2005. 46: 350–355.
25. Dayan B. Goodenowe,1, Lisa L. Cook, Jun Liu, et al.
    Peripheralethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer’s disease and dementia.
    J. Lipid Res. 2007. 48: 2485–2498.
    
26. Ernst J. Schaefer, MD; Vanina Bongard, et al.
    Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease.
    The Framingham Heart Study. Arch Neurol . 2006;63:1545-1550.
27. Hyun Pyo Kim , Kun Ho Son , Hyeun Wook Chang, and Sam Sik Kang
    Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms.
    J Pharmacol Sci 2004; 96, 229–245.
28. MichiyoTomita, BritaJHolman, Christopher P Santoro and Thomas J Santoro
    Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription.
    Journal of Neuroinflammation 2005, 2:8 doi:10.1186/1742-2094-2-8.
29. Hee-Sung KIM, Jae-young CHO, Do-Hoon KIM, Ji-Jing YAN, Han-Kyu LEE, Hong-Won SUH, and Dong-Keun SONG.
    Inhibitory Effects of Long-Term Administration of Ferulic Acid on Microglial Activation Induced by Intracerebroventricular Injection of -Amyloid Peptide (1—42) in Mice.
    Biol. Pharm. Bull. 2004;27(1) 120—121.
    Ji-Jing Yan, Jae-Young Cho, Hee-Sung Kim, et al.
    Protection against b-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. British Journal of Pharmacology (2001) 133, 89 – 96.
30. Palwinder Mander and Guy C Brown
    Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration.
    Journal of Neuroinflammation 2005, 2:20 doi:10.1186/1742-2094-2-20.
31. Delarue J, LeFoll C, Corporeau C, Lucas D.
    N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?
    Reprod Nutr Dev. 2004 May-Jun;44(3):289-99.
32. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM.
    Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model.
    Neuron. 2004;43:633-45.
33. Hu Y, Liu Z, Ye K.
    Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.
    Proc Natl Acad Sci U S A. 2005;102:16853-8.
34. Zhihong Lin, Danni Zhu, Yongqing Yan, et al.
    An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress.
    eCAM 2008;Page 1 of 7 doi:10.1093/ecam/nen053.
35. Zhi-zhong GUAN
    Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease.
    Acta Pharmacologica Sinica 2008 July; 29 (7): 773-780
36. Jeremy P. E. Spencer.
    The interactions of flavonoids within neuronal signalling pathways.
    Genes Nutr 2007 2:257–273.
37. Leiro J, Arranz JA, Fraiz N, Sanmartin ML, Quezada E, Orallo F.
    Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling.
    Int Immunopharmacol. 2005;5:393-406.
38. Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Zhao YQ, Wu CF.
    Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia.
    Int Immunopharmacol. 2005;5:185-93.
39. Anders A.F. Sima, Menotti Calvani, et al.
    Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy An analysis of two randomized placebo-controlled trials.
    Diabetes Care 28:89-94, 2005.
40. Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C.
    Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging.
    Clin Nutr. 2005;24:794-800.
41. Savitha S, Tamilselvan J, Anusuyadevi M, Panneerselvam C.
    Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine.
    Clin Chim Acta. 2005;355:173-80.
42. Arivazhagan P, Panneerselvam C.
    Alpha-lipoic acid increases Na+K+ATPase activity and reduces lipofuscin accumulation in discrete brain regions of aged rats.
    Ann N Y Acad Sci. 2004;1019:350-4.
43. Mann BA, Garry PJ, Hunt WC, Owen GM, Goodwin JS.
    Daily multivitamin supplementation and vitamin blood levels in the elderly: a randomized, double-blind, placebo-controlled trial.
    J Am Geriatr Soc. 1987;35:302-6.
44. Kumar Sudhir
    Vitamin B12 deficiency presenting with an acute reversible extrapyramidal syndrome.
    2004;52: 507-509.
45. Charles Vega
    Older Adults May Need B12 Dose More Than 200 Times the RDA to Normalize Mild Vitamin Deficiency.
    Medscape Medical News CME.
46. Vijay Ganji and Mohammad R. Kafai
    Trends in Serum Folate, RBC Folate, and Circulating Total Homocysteine Concentrations in the United States: Analysis of Data from National Health and Nutrition Examination Surveys, 1988–1994, 1999–2000, and 2001–2002.
    J. Nutr. 136: 153–158, 2006.
47. Bala K, Tripathy BC, Sharma D.
    Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions.
    Biogerontology. 2006;7:81-9.
48. Kaur J, Sharma D, Singh R.
    Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.
    Neurosci Lett. 2001 Mar 23;301:1-4.
    Ames BN, Liu J.
    Delaying the mitochondrial decay of aging with acetylcarnitine.
    Ann N Y Acad Sci. 2004;1033:108-16.
49. Xu Y, Ku B, Tie L, Yao H, Jiang W, Ma X, Li X.
    Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.
    Brain Res. 2006;1122:56-64.
50. Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H.
    Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation.
    Neuroreport. 2008;19:1329-33.
    
51. Huang WT, Niu KC, Chang CK, Lin MT, Chang CP.
    Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits.
    Eur J Pharmacol. 2008;593:105-11.
52. Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK
    Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice.
    Phytother Res. 2008;22:1660-1664.
53. Wang R, Li YB, Li YH, Xu Y, Wu HL, Li XJ.
    Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.
    Brain Res. 2008;1210:84-91.
54. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.
    Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
    J Biol Chem. 2005;280:5892-901
55. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM.
    The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.
    J Neurosci. 2001;21:8370-7.
56. Cole GM, Frautschy SA.
    Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model.
    Nutr Health. 2006;18(3):249-59.
57. Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J.
    Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus.
    J Biol Chem. 2008;283:14497-505.
    Shukla PK, Khanna VK, Ali MM, Khan MY, Srimal RC
    Anti-ischemic effect of curcumin in rat brain.
    Neurochem Res. 2008;33:1036-43.
58. Thiyagarajan M, Sharma SS.
    Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats.
    Life Sci. 2004;74:969-85.
59. Jagatha B, Mythri RB, Vali S, Bharath MM.
    Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies.
    Free Radic Biol Med. 2008;44:907-17.
60. Kumar A, Naidu PS, Seghal N, Padi SS.
    Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.
    Pharmacology. 2007;79:17-26.
61. Jin CY, Lee JD, Park C, Choi YH, Kim GY.
    Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia.
    Acta Pharmacol Sin. 2007;28:1645-51.
62. Kuhad A, Chopra K.
    Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences.
    Eur J Pharmacol. 2007;576:34-42.
63. Reznichenko L, Amit T, Zheng H, Avramovich-Tirosh Y, Youdim MB, Weinreb O, Mandel S.
    Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease.
    J Neurochem. 2006;97:527-36.
64. Avramovich-Tirosh Y, Reznichenko L, Mit T, Zheng H, Fridkin M, Weinreb O, Mandel S, Youdim MB.
    Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.
    Curr Alzheimer Res. 2007;4:403-11.
    Xu Y, Ku B, Tie L, Yao H, Jiang W, Ma X, Li X.
    Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.
    Brain Res. 2006;1122:56-64.
65. Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ.
    Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.
    J Neurochem. 2007;102:1095-104.
66. Bengmark S.
    Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.
    JPEN J Parenter Enteral Nutr. 2006;30:45-51.
67. Dairam A, Limson JL, Watkins GM, Antunes E, Daya S.
    Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats.
    J Agric Food Chem. 2007;55:1039-44.
68. Daniel S, Limson JL, Dairam A, Watkins GM, Daya S.
    Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain.
    J Inorg Biochem. 2004;98:266-75.
69. Mythri RB, Jagatha B, Pradhan N, Andersen J, Bharath MM.
    Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?
    Antioxid Redox Signal. 2007;9:399-408.
70. Pinilla FG.
    The impact of diet and exercise on brain plasticity and disease.
    Nutr Health. 2006;18:277-84.
71. Wu A, Ying Z, Gomez-Pinilla F.
    Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition.
    Exp Neurol. 2006;197:309-17.
72. Jung KK, Lee HS, Cho JY, Shin WC, Rhee MH, Kim TG, Kang JH, Kim SH, Hong S, Kang SY.
    Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia.
    Life Sci. 2006;79:2022-31.
73. Bala K, Tripathy BC, Sharma D.
    Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions.
    Biogerontology. 2006;7:81-9.
74. Al-Omar FA, Nagi MN, Abdulgadir MM, Al Joni KS, Al-Majed AA
    Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.
    Neurochem Res. 2006;31:611-8.
    
75. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ.
    Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats.
    Pharmacol Biochem Behav. 2005;82:200-6.
76. Zhu YG, Chen XC, Chen ZZ, Zeng YQ, Shi GB, Su YH, Peng X
    Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons.
    Acta Pharmacol Sin. 2004;25:1606-12.
77. Baum L, Ng A.
    Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.
    J Alzheimers Dis. 2004;6:367-77
78. Rajakrishnan V, Viswanathan P, Rajasekharan KN, Menon VP.
    Neuroprotective role of curcumin from curcuma longa on ethanol-induced brain damage.
    Phytother Res. 1999;13:571-4.
79. Sreejayan, Rao MN.
    Curcuminoids as potent inhibitors of lipid peroxidation.
    J Pharm Pharmacol. 1994;46:1013-6.
80. Soudamini KK, Unnikrishnan MC, Soni KB, Kuttan R.
    Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin.
    Indian J Physiol Pharmacol. 1992;36:239-43.
81. Sultana R, Ravagna A, Mohmmad-Abdul H, Calabrese V, Butterfield DA.
    Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stressand neurotoxicity: relationship to antioxidant activity.
    J Neurochem. 2005;92:749-58.
82. Kumar A, Goyal R.
    Quercetin protects against acute immobilization stress-induced behaviors and biochemical alterations in mice.
    J Med Food. 2008 ;11:469-73.
83. Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA.
    Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease.
    J Nutr Biochem. 2008 Jul 3
84. Silva B, Oliveira PJ, Dias A, Malva JO.
    Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults.
    Neurotox Res. 2008;13:265-79.
85. Rivera F, Costa G, Abin A, Urbanavicius J, Arruti C, Casanova G, Dajas F.
    Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats.
    Neurotox Res. 2008;13:105-14.
86. Vauzour D, Ravaioli G, Vafeiadou K, Rodriguez-Mateos A, Angeloni C, Spencer JP.
    Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.
    Arch Biochem Biophys. 200815;476:145-51.
87. Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K, Fujiwara M.
    Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats.
    J Pharmacol Sci. 2007;104:329-34
88. Liu J, Yu H, Ning X.
    Effect of quercetin on chronic enhancement of spatial learning and memory of mice.
    Sci China C Life Sci. 2006 Dec;49(6):583-90.
89. Park JW, Jang YH, Kim JM, Lee H, Park WK, Lim MB, Chu YK, Lo EH, Lee SR.
    Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia.
    J Neurosci Res. 2008 Aug 27. [Epub ahead of print]
90. Lee S, Suh S, Kim S.
    Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils.
    Neurosci Lett. 2000;287:191-4.
91. Lee H, Bae JH, Lee SR.
    Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils.
    J Neurosci Res. 2004;77:892-900.
92. Mandel S, Weinreb O, Amit T, Youdim MB.
    Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.
    J Neurochem. 2004;88:1555-69.
93. Weinreb O, Mandel S, Amit T, Youdim MB.
    Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases.
    J Nutr Biochem. 2004 Sep;15(9):506-16.
94. Pan T, Jankovic J, Le W.
    Potential therapeutic properties of green tea polyphenols in Parkinson's disease.
    Drugs Aging. 2003;20(10):711-21.
95. Mandel SA, Avramovich-Tirosh Y, Reznichenko L, Zheng H, Weinreb O, Amit T, Youdim MB.
    Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway.
    Neurosignals. 2005;14:46-60.
96. Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MB.
    Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders.
    Mol Nutr Food Res. 2006;50:229-34.
97. Mandel S, Youdim MB.
    Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases.
    Free Radic Biol Med. 2004 ;37:304-17.
98. Shichiri M, Takanezawa Y, Uchida K, Tamai H, Arai H.
    Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity.
    Brain Res. 2007;1182:106-15.
99. Sen CK, Khanna S, Roy S.
    Tocotrienol: the natural vitamin E to defend the nervous system?
    Ann N Y Acad Sci. 2004;1031:127-42.
    
100. Sen CK, Khanna S, Roy S, Packer L.
     Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells.
     J Biol Chem. 2000;275:13049-55.
101. Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK.
     Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol.
     J Neurochem. 2006;98:1474-86.
102. Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A.
     Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.
     Neuropharmacology. 2004;47:904-15.
103. Khanna S, Roy S, Ryu H, Bahadduri P, Swaan PW, Ratan RR, Sen CK.
     Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.
     J Biol Chem. 2003;278:43508-15.
104. Gürsoy M, Büyükuysal RL.
     Resveratrol protects rat striatal slices against anoxia-induced dopamine release.
     Neurochem Res. 2008;33:1838-44.
105. Okawara M, Katsuki H, Kurimoto E, Shibata H, Kume T, Akaike A.
     Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.
     Biochem Pharmacol. 2007;73:550-60.
106. Anekonda TS.
     Resveratrol--a boon for treating Alzheimer's disease? Brain Res Rev. 2006;52:316-26.
     J Neurochem. 2006;96:305-13.
107. Cho JY, Kim IS, Jang YH, Kim AR, Lee SR.
     Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia.
     Neurosci Lett. 2006;404:330-5.
108. Mocchegiani E, Malavolta M.
     Possible new antiaging strategies related to neuroendocrine-immune interactions.
     Neuroimmunomodulation. 2008;15:344-50.
109. Hipkiss AR.
     On the enigma of carnosine's anti-ageing actions.
     Exp Gerontol. 2008.
110. Hipkiss AR, Brownson C, Carrier MJ.
     Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.
     Mech Ageing Dev. 2001;122:1431-45.
111. Kozan R, Sefil F, Bag˘ırıcı F.
     Anticonvulsant effect of carnosine on penicillin-induced epileptiform activity in rats.
     Brain Res. 2008 Aug 16. [Epub ahead of print].
112. Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Kozlova E, Boldanova N, Bagyeva G, Ivanova-Smolenskaya I, Illarioshkin S.
     Carnisone increases efficiency of DOPA therapy of Parkinson's disease: a pilot study.
     Rejuvenation Res. 2008;11:821-7.
113. Velez S, Nair NG, Reddy VP.
     Transition metal ion binding studies of carnosine and histidine: biologically relevant antioxidants.
     Colloids Surf B Biointerfaces. 2008;66:291-4.
114. Reddy VP, Garrett MR, Perry G, Smith MA.
     Carnosine: a versatile antioxidant and antiglycating agent.
     Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
115. Hipkiss AR, Preston JE, Himsworth DT, et al.
     Pluripotent protective effects of carnosine, a naturally occurring dipeptide.
     Ann N Y Acad Sci. 1998;854:37-53.
116. Wang AM, Ma C, Xie ZH, Shen F.
     Use of carnosine as a natural anti-senescence drug for human beings.
     Biochemistry (Mosc). 2000;65:869-71.
117. Hipkiss AR.
     Carnosine, a protective, anti-ageing peptide?
     Int J Biochem Cell Biol. 1998;30:863-8.
118. Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E.
     Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity.
     Neurochem Res. 2008;33:2444-71.
119. Min J, Senut MC, Rajanikant K, Greenberg E, et al.
     Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.
     J Neurosci Res. 2008;86:2984-91.
120. Kawahara M, Konoha K, Nagata T, Sadakane Y.
     Protective substances against zinc-induced neuronal death after ischemia: carnosine as a target for drug of vascular type of dementia.
     Recent Patents CNS Drug Discov. 2007;2:145-9.